Circadian regulation of allergic reactions by immune cell-clocks

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04864
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: University of Yamanashi
• Principal Investigator: NAKAO Atsuhito 山梨大学, 大学院総合研究部, 教授 (80317445)
• Research Collaborator: NAKAMURA Yuki ; ISHIMARU Kayoko
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アレルギー / 概日時計 / 免疫細胞

Outline of Final Research Achievements

We have established dendritic cell-selective Bmal1-deficient mice (DC-Bmal1-deficient mice) in this study.
Upon introduction of Derf1, a major mite allergen,-induced asthma model, DC-Bmal1-deficient mice showed reduced airway inflammation associated with suppression of Derf1-specific IgE antibody and T cell responses. Preliminary studies showed that migration of dendritic cells into the regional lymph nodes were suppressed in DC-Bmal1-deficient mice. These findings suggest that deficiency of Bmal1 in dendritic cells suppresses sensitization to Derf1 by inhibition migration of DC to lymph nodes. We are under investigation how the suppression of DC migration occurs in DC-Bmal1-deficient mice.

Free Research Field

アレルギー