Development of a new therapy through the clarification of innate immune receptor for PAMPs in children with vasculitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04877
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Fukuoka Children’s Hospital (2017); Kyushu University (2015-2016)
• Principal Investigator: Hara Toshiro 地方独立行政法人福岡市立病院機構福岡市立こども病院(臨床研究部), 臨床研究部, 院長 (40150445)
• Co-Investigator(Kenkyū-buntansha): 西尾 壽乘 九州大学, 大学病院, 助教 (00507783) ; 宮本 智文 九州大学, 薬学研究院, 准教授 (40182050) ; 山崎 晶 九州大学, 生体防御医学研究所, 教授 (40312946)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 自然免疫 / 川崎病 / PAMPs

Outline of Final Research Achievements

With the improvement of extraction method and by the comprehensive high resolution LC-MS analysis of 10 independent KD samples, we selected KD-specific molecules with levels significantly higher than those of controls at least in 2 different periods.
We prospectively analyzed these molecules in 7 independent KD clusters. The KD-specific molecules were detected in all, except for one incomplete case. Some KD-specific molecules were significantly associated with the degree of inflammation, and the formation of coronary artery lesions. Some of the KD-specific molecules showed MS/MS fragments similar to those of biofilm products from Yersinia pseudotuberculosis. KD-specific molecules appear to be involved in the pathophysiology of KD and the development of coronary artery lesions.

Free Research Field

臨床免疫