Comprehensive analysis of factors related to functional recovery of severe heart failure by surgical unloading

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04936
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Chiba University
• Principal Investigator: MATSUMIYA Goro 千葉大学, 大学院医学研究院, 教授 (20314312)
• Co-Investigator(Kenkyū-buntansha): 石田 敬一 千葉大学, 大学院医学研究院, 特任准教授 (40375671) ; 上田 秀樹 千葉大学, 医学部附属病院, 講師 (50738987) ; 黄野 皓木 千葉大学, 医学部附属病院, 助教 (40375803) ; 松浦 馨 千葉大学, 医学部附属病院, 助教 (50436375) ; 田村 友作 千葉大学, 医学部附属病院, 助教 (60738988) ; 渡邉 倫子 千葉大学, 医学部附属病院, 助教 (20766274)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 心不全 / 心筋症 / リモデリング / 補助人工心臓

Outline of Final Research Achievements

We sought to examine whether RNA sequencing of myocardial tissue samples can identify any useful factor to predict reverse remodeling of left ventricle in response to optimal medical management. Dilated cardiomyopathy patients with LVEF below 30% and NYHA class III or IV symptoms were analyzed. No difference were found in preoperative clinical parameters. RNA sequencing identified upregulated genes in non-reverse remodeling group, which encode mitochondrial respiratory chain complex and proteins involved p38 MAP kinase dependent cell death.

Free Research Field

心臓血管外科学