Development of strategies for anesthesia emergence and tracheal extubation in patients with obstructive sleep apnea

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04967
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Chiba University
• Principal Investigator: ISONO SHIROH 千葉大学, 大学院医学研究院, 教授 (80212968)
• Co-Investigator(Kenkyū-buntansha): 石川 輝彦 千葉大学, 大学院医学研究院, 准教授 (30272305)
• Co-Investigator(Renkei-kenkyūsha): OKAZAKI Junko 千葉大学, 大学院医学研究院, 助教 (80645531) ; KITAMURA Yuji 千葉大学, 医学部附属病院, 助教 (00436388)
• Research Collaborator: SATO Shin ; KATO Shinichiro ; MURAMATSU Takahiro ; SHINOHARA Ayako ; SUGANUMA Emiri
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 閉塞性睡眠時無呼吸 / 周術期気道管理 / 麻酔覚醒 / 抜管 / 高炭酸ガス

Outline of Final Research Achievements

In order to establish safe strategy for anesthesia emergence and tracheal extubation in patients with obstructive sleep apnea, we explored detailed recovery process of consciousness level, respiration, circulation and their interactions, and tested influences of hypercapnia on emergence time and incidence of harmful airway reflexes during emergence from general anesthesia. Furthermore, we confirmed higher incidence of recurarization after injection of inadequate dose of sugammadex, and importance of alertness in recovery of upper and lower esophageal sphincters. Perioperative airway management strategy for patients with obstructive sleep apnea was established during the study period.

Free Research Field

麻酔科学、睡眠学、生理学