Lipid and steroid metabolism and prostate cancer using imaging mass-spectrometry

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04971
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Gunma University
• Principal Investigator: Suzuki Kazuhiro 群馬大学, 大学院医学系研究科, 教授 (80312891)
• Co-Investigator(Kenkyū-buntansha): 伊藤 一人 群馬大学, 大学院医学系研究科, 准教授 (00302472) ; 関根 芳岳 群馬大学, 大学院医学系研究科, 助教 (00516370) ; 松井 博 群馬大学, 重粒子線医学推進機構, 講師 (40450374) ; 柴田 康博 群馬大学, 医学部附属病院, 講師 (90344936) ; 小池 秀和 群馬大学, 医学部附属病院, 講師 (90420091)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 前立腺癌 / 脂質 / ステロイド

Outline of Final Research Achievements

Prostate cancer is an adrogen-dependent cancer. Lipid, which is a substrate of androgen, plays an important role on prostate cancer proliferation. In this study, we studied the localization and mass-distribution of testosterone, dihydrotestosterone and cholesterol in prostate cancer tissues using the imaging mass-spectrometry. Testosterone, dihydrotestosterone and cholesterol have their own molecular wights, and these molecules were able to be quantified by mass-spectrometry. Simultaneous histological analyses were feasible, and imaging mass-spectromery would be considered as efficient. We also studied the role of statin, inhibitor of HMG-CoA reductase, on prostate cancer proliferation. We found that LDL receptor and annexin A10 were involved in the regulation of prostate cancer proliferation under control of statin.

Free Research Field

泌尿器科学