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2017 Fiscal Year Final Research Report

Development of novel diagnosis and therapeutic procedures for nasal NK/T-cell lymphoma consists of targeting EBV-associated molecules

Research Project

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Project/Area Number 15H04986
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionAsahikawa Medical College

Principal Investigator

Harabuchi Yasuaki  旭川医科大学, 医学部, 教授 (80208686)

Co-Investigator(Kenkyū-buntansha) 高原 幹  旭川医科大学, 医学部, 講師 (50322904)
長門 利純  旭川医科大学, 医学部, 助教 (80431419)
岸部 幹  旭川医科大学, 医学部, 講師 (80447101)
小林 博也  旭川医科大学, 医学部, 教授 (90280867)
上田 征吾  旭川医科大学, 医学部, 助教 (90447102)
駒林 優樹  旭川医科大学, 医学部, 助教 (40548864)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords頭頸部外科学
Outline of Final Research Achievements

We generated murine xenograft models inoculated with an natural killer/T-cell lymphoma cell line and revealed that sPD-L1 could be a prognostic predictor for NNKTL and open up the pos- sibility of immunotherapy of this lymphoma using PD-1/ PD-L1 axis inhibitors.
We revealed that circulating EBV‐miRNAs, particularly miR‐BART2‐5p, may serve as potential diagnostic and prognostic biomarkers in patients with nasal natural killer/T-cell lymphoma.

Free Research Field

悪性腫瘍

URL: 

Published: 2019-03-29  

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