2017 Fiscal Year Final Research Report
Elucidation of microRNA methylation mechanism for high precision cancer diagnosis
| Project/Area Number |
15H05664
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 癌 / 臨床 / 遺伝子 / 核酸 |
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| Outline of Final Research Achievements |
By recent studies of the RNA methylation mechanism, it has been known that the RNA functions as an important regulator of gene expression by dynamically converting its methylation state as the DNA and histone do. In the present study, we then clarified the clinical significance of methylated miRNAs by the comprehensive profiling in cancer and improved accuracy of miRNAs as cancer biomarkers by studying the methylation. As a result, the mechanism of microRNA methylation was clarified and we constructed further the foundation for accurate diagnosis in the precision medicine.
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| Free Research Field |
遺伝子機能解析
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