Analysis of the effect of microRNA-33 on bone marrow function and chronic inflammation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06335
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: Baba Osamu 京都大学, 医学研究科, 医員 (30758446)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: マイクロRNA / 単球 / HDLコレステロール / ABCA1 / HMGA2

Outline of Final Research Achievements

In the present study, we analyzed the effect of microRNA (miR)-33 on leukocyte population and bone marrow function. As a result, the expression of High mobility group AT-hook 2 (HMGA2) targeted by miR-33 was increased in hematopoietic stem cells in miR-33 deficient mice, which reduced their apoptosis and subsequently increased hematopoietic stem cell, myeloid progenitor and monocyte population in bone marrow. On the other hand, miR-33 is known to increase HDL cholesterol by targeting ATP-binding cassette transporter A1 (ABCA1). We also demonstrated that this increase in HDL cholesterol suppressed the emigration of monocytes from bone marrow to peripheral blood, which decreased peripheral inflammatory monocytes in miR-33 deficient mice.

Free Research Field

循環器内科学