Role of IFN-gamma in elimination of intracellularly invaded oral bacteria and disease progression.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06382
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: Ohshima Jun 大阪大学, 歯学研究科, 助教 (30755450)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 微生物学

Outline of Final Research Achievements

The purpose of this study was to investigate the binding molecule of Gbp, a kind of IFN-gamma-inducible GTPase, and to try to elucidate the regulatory mechanism of IFN-gamma-induced GTPases' function.　In addition, we aimed to clarify the mechanism of progression and prolongation of periodontal disease by examining the relationship between host defense through IFN-gamma and oral bacteria invading into the host cells. As a result, we were able to identify RabGDI-alpha as a novel molecule that binds to Gbp2 and negatively regulates its function. Also, it was suggested that IFN-gamma is involved in elimination of intracellularly invaded oral bacteria and subsequent production of inflammatory cytokines and that P. gingivalis has an unknown mechanism to negatively control IFN-signaling.

Free Research Field

歯学