Studies on mechanism of metabolic regulation of vitamin A and beta-carotene and their nutritional status-related biological regulation.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00835
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Nagasaki
• Principal Investigator: SURUGA KAZUHITO 長崎県立大学, 看護栄養学部, 准教授 (70315852)
• Co-Investigator(Kenkyū-buntansha): 山口 範晃 長崎県立大学, 看護栄養学部, 助教 (80516295)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ビタミンA / β-カロテン / アルコール / 高脂肪食 / 妊娠・授乳期 / 耐糖能異常 / ロコモティブシンドローム

Outline of Final Research Achievements

Intake of alcohol and high-fat diet led to suppress the oxidative cleavage conversion of beta-carotene into vitamin A via alteration of expression level of two ranscription factors, ISX and PPAR-delta, in rat small intestine. Vitamin A-nutritional status during pregnancy/lactation affected the synthesis and catabolism of retinoic acid and the absorption and metabolic function of β-carotene in rat pups during the peri-weaning period. Sufficient ingestion of dietary vitamin A and β-carotene resulted in improving impaired glucose tolerance and abnormal lipid metabolism.

Free Research Field

栄養生理学