Prospects of inflammation resolving potential of n-3 polyunsaturated fatty acids for improvement of the prognosis in a rat model of pulmonary hypertension.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00837
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Iwate Medical University
• Principal Investigator: Saito Maki 岩手医科大学, 薬学部, 助教 (40365185)
• Co-Investigator(Kenkyū-buntansha): 田辺 由幸 横浜薬科大学, 薬学部, 教授 (10275109) ; 鎌滝 章央 弘前大学, 医学研究科, 助教 (60360004)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺高血圧症 / 魚油 / コーン油 / アスピリン

Outline of Final Research Achievements

It has been reported that n-3 polyunsaturated fatty acids, such as EPA and DHA, which are contained richly in fish oil, are converted into inflammation resolving molecules called “resolvins” by aspirin-acetylated cyclooxygenase-2. The aim of the present study is to clarify whether co-administration of fish oil and aspirin improves symptoms of pulmonary hypertension (PH) and inflammation in monocrotaline-induced pulmonary hypertensive rat model.
Contrary to expectations, co-administration of fish oil and aspirin led to exacerbation of right ventricular hypertrophy in the monocrotaline-treated rats. Moreover, expression of inflammatory cytokines including IL-1 was augmented in the right ventricles. These results suggest that excessive intake of health food including EPA and DHA, may adversely affect proper pharmaceutical therapy.

Free Research Field

薬理学