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2017 Fiscal Year Final Research Report

Mechanisms of insulin resistance induced by trans fatty acids and applications in clinical nutrition

Research Project

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Project/Area Number 15K00842
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionSeitoku University

Principal Investigator

YOKOYAMA Yoshiko  聖徳大学, 人間栄養学部, 准教授 (40202395)

Co-Investigator(Kenkyū-buntansha) 加納 和孝  聖徳大学, 人間栄養学部, 教授 (70111507)
神野 茂樹  聖徳大学, 人間栄養学部, 教授 (10251224)
田部井 功  東京慈恵会医科大学, 医学部, 講師 (50266649)
Co-Investigator(Renkei-kenkyūsha) Shiraishi Hiromi  人間総合科学大学, 人間科学部, 教授 (50572640)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsインスリン抵抗性 / トランス脂肪酸 / TNF-α
Outline of Final Research Achievements

It is known that insulin resistance is increased by ingestion of trans fatty acids,but detailed biochemical analysis of the process has not been conducted. In this study with YMB-1-E and other cells, I showed the attenuation of insulin receptor and its substrate-1 proteins, the inhibition of tyrosine residue phosphorylation, the inhibition of serine residue phosphorylation of these proteins and also the enhancement of TNF-α production by elaidic acid. EPA worked inhibitory to these responses. These results suggest the possibility of improving insulin resistance by reviewing trans fatty acid intake.

Free Research Field

食生活学

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Published: 2019-03-29  

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