2017 Fiscal Year Final Research Report
Effect of maternal nutrition during pregnancy on lipid metabolism including lipid absorption of offspring
| Project/Area Number |
15K00860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 裕滋 近畿大学, 医学部附属病院, 講師 (00465650)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 脂質代謝 / 胆汁酸代謝 / エピジェネティック / 性差 |
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| Outline of Final Research Achievements |
Dietary fat affect the gene expression related to lipid metabolism both in liver and intestine. Maternal high-fat diet (HFD) consumption during pregnancy and lactation affects lipid metabolism of offspring in later life. The purpose of this study was to elucidate the effect of maternal fat intake on metabolic alteration of intestine as well as liver in male and female adult mice offspring. Female mice were fed either standard chow (C) or HFD (H). Offspring were fed a chow diet until eleven weeks, then challenged with either C or H diet, and divided into eight groups in accordance with mother's and offspring’s diets: male(M) CC, MHC, MCH, MHH, female(F) CC, FHC, FCH, and FHH. Hepatic expression of Oatp1a1 and Oatp1b2 was increased in MHH, compared to MCH. Hepatic expression of HMGCoAR, Cyp7a1, Sult2a1, and Oatp1a4 was increased in FHH, compared to FCH. On the other hand, intestinal mRNA expression of adult offspring was not affected by the maternal HFD.
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| Free Research Field |
代謝学
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