Real-time imaging for innovative design of bone substitute materials.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01278
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAGAI Akiko 東京医科歯科大学, 生体材料工学研究所, 准教授 (40360599)
• Co-Investigator(Kenkyū-buntansha): 野崎 浩佑 東京医科歯科大学, 生体材料工学研究所, 助教 (00507767) ; 堀内 尚紘 東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
• Research Collaborator: MASUDA Hiroshi 久留米大学, 医学部, 准教授 (10321861)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 機能性骨補填材 / アパタイトナノ薄膜 / リアルタイムイメージング

Outline of Final Research Achievements

In this study, we aimed to evaluate interactions between the living body and implant materials by real-time imaging to develop functional bone substitutes.
Hydroxyapatite nanoparticles were prepared using self-organization of organic molecule. Nano-thin film was formed on glass, and stem cells or osteoblasts were cultured on it. Cell behaviors such as cell attachments or endocytosis could observed in real-time.
Real-time imaging for interactions between bone tissues and implants (hydroxyapatite porous bodies) were observed using the cranial window method. Bone formation started around the damaged bone with lacking in material-side by confocal microscopy observations. The result linked the difference between a bone prosthetic material and an autologous bone in the repair of bone and suggested the idea of development for innovative materials.

Free Research Field

生体材料