Assessment of diabetic cardiomyopathy using handgrip stress speckle tracking echocardiography

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: The University of Tokyo
• Principal Investigator: Kawata Takayuki 東京大学, 医学部附属病院, 助教 (20532526)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 負荷心エコー / ストレイン / 糖尿病性心筋障害

Outline of Final Research Achievements

Assessment of left ventricular global longitudinal strain (GLS) was performed at baseline and after handgrip stress in patients with and without diabetes mellitus using 2D speckle tracking echocardiography. Baseline GLS was significantly lower in diabetes (-19.3) compared to those without diabetes (-20.9). After handgrip stress, GLS of both groups was significantly decreased (patients with diabetes, -19.3 to -17.0, patients without diabetes, -20.9 to -19.3). Moreover, GLS of diabetes was significantly decreased compared to GLS of nondiabetes after stress, and interaction existed between diabetes and reduction of GLS. These results suggest that latent contractile reserve is reduced in diabetes patients.

Free Research Field

心エコー図、循環器