The role of apoE-rich HDL in lifestyle diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01715
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Okayama University
• Principal Investigator: USUI SHINICHI 岡山大学, 保健学研究科, 准教授 (50346417)
• Co-Investigator(Kenkyū-buntansha): 廣畑 聡 岡山大学, 保健学研究科, 教授 (90332791)
• Co-Investigator(Renkei-kenkyūsha): SHINOHATA Ryoko 岡山大学, 大学院保健学研究科, 助教 (70335587)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: HDL / アポリポ蛋白E / 肥満 / 生活習慣病モデルマウス

Outline of Final Research Achievements

In this study, we established a quantitative method for serum apoE-rich HDL and showed that apoE-rich HDL increased in obese model mice. In clinical study, multiple regression analysis revealed that triglycerides and adiponectin strongly involved in obesity are significant predictors of apoE-rich HDL-cholesterol levels. However, in the culture experiment of adipocytes, we did not obtain data on which apoE-rich HDL was involved in fat accumulation. In cultured hepatocytes, the production of apoE-rich HDL was increased by the high glucose medium, suggesting that glucose uptake by hepatocytes was significantly involved in the production of apoE-rich HDL. A new research progress is expected in the future in relation to glucose metabolism and the production of E-rich HDL in hepatocytes.

Free Research Field

臨床化学検査