The elucidation of underlying mechanism and the establishment of therapeutic strategy on the abnormal bone metabolism of diabetes

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K01725
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kyorin University
• Principal Investigator: Takahashi Kazuto 杏林大学, 医学部, 助教 (80508292)
• Co-Investigator(Kenkyū-buntansha): 石田 均 杏林大学, 医学部, 教授 (80212893)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 骨代謝 / 糖尿病

Outline of Final Research Achievements

TNF-α, a main cytokine deprived from osteoclasts, stimulation have increased MCP-1 secretion from UMR106 osteoblast, and IL-1β, the same factor, enhanced VEGF120, and both MCP-1 and VEGF120 are considered to be the factors which can differentiate monocytes into osteoclasts and activate them in the abnormal bone metabolism of diabetes. On the other hand, the heat treatment at 41 ℃ for 20 min diminished the augmentation of MCP-1 and VEGF120 secretions. Furthermore, this down-regulation appears to play on the post-transcription levels. But HSP72 had no effects on the attenuation of MCP-1 and VEGF120 secretions by heat treatment. Thus, short term heat exposure may block the development of the abnormal bone metabolism of diabetes, and this inhibitory effect seems to operate in the post-transcription levels.

Free Research Field

医学

Academic Significance and Societal Importance of the Research Achievements

糖尿病骨代謝異常は、新たな糖尿病合併症として注目されているが、その病態に関し正確なメカニズムが不明であった。従って、本研究により、糖尿病骨代謝異常における基盤病態の一端が明らかになったと考えられる。そして、本研究を基に糖尿病骨代謝異常の病態のさらなる解明、ならびにその治療法や予防策に関する研究が進行していくものと信じられる。