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2017 Fiscal Year Final Research Report

Structure and function of a signal protein osteocalcin connncting bone metabolism and carbohydrate metabollism

Research Project

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Project/Area Number 15K01805
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomolecular chemistry
Research InstitutionChitose Institute of Science and Technology

Principal Investigator

Kawano Keiichi  千歳科学技術大学, 理工学部, 特別研究員 (10136492)

Co-Investigator(Renkei-kenkyūsha) Karthaus Olaf  千歳科学技術大学, 理工学部, 教授 (80261353)
KIMURA Hiromi  千歳科学技術大学, 理工学部, 教授 (00574857)
Research Collaborator KOBAYASHI Shota  
AIZAWA Tomoyasu  
MIZUGUCHI Mineyuki  
YOKOYAMA Takeshi  
NABESHIMA Yuko  
HIRATA Masato  
Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsオステオカルシン / 多臓器相関 / 糖代謝 / 骨形成 / 立体構造解析 / NMR / X線結晶解析 / 活性型
Outline of Final Research Achievements

Osteocalcin (OC), which was known as a protein useful for the formation of bone, has been found to be a hormone with various activities such as control of sugar metabolism, lipid metabolism, production of testosterone. Stimulation of bones is known as a key of health and rejuvenation. Despite its importance, a little of molecular mechanisms are known. Since OC is activated in an acidic environment, the three-dimensional structures of OC in acidic state were examined by CD, NMR and X-ray crystallography. As a result, it was revealed that OC is able to maintain structure and hormonal activity even in acidic environment.

Free Research Field

構造生物学

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Published: 2019-03-29  

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