White box testing of nanomedicines on a microfluidic device

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K04640
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nano/Microsystems
• Research Institution: Toyo University
• Principal Investigator: Sasaki Naoki 東洋大学, 理工学部, 准教授 (30462691)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ナノ薬剤 / 血管透過性 / 共培養 / レーザー加工

Outline of Final Research Achievements

Nanoparticles have been widely utilized to deliver drugs from blood vessels to tumor tissues. In this study, we developed a microfluidic device to clarify nanoparticle characteristics required for efficient drug delivery. A consumer laser cutter was employed to fabricate the device. Tumor cells and vascular endothelial cells were co-cultured on a membrane-integrated microfluidic device. Permeation of nanoparticles through the endothelial monolayer increased in the presence of tumor cells.

Free Research Field

マイクロ・ナノ分析化学