Analysis of digestion characteristics of foods by developing a human duodenum digestion simulator equipped with peristalsis function

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06590
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: KOBAYASHI Isao 国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, 上級研究員 (70425552)
• Co-Investigator(Renkei-kenkyūsha): ICHIKAWA Sosaku 筑波大学, 生命環境系, 教授 (00292516)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 十二指腸 / 食品 / 消化 / ぜん動運動 / in vitro消化 / 混合 / 酵素反応

Outline of Final Research Achievements

Evaluation of mixing and digestion behaviors of duodenum contents is important for understanding and controlling adsorption of nutritional components in the small intestine. In this research, we newly developed a human duodenum digestion simulator equipped with peristaltic motion and secretion of a digestive fluid on the duodenum wall. The use of this human duodenum digestion simulator was capable of quantitatively evaluating fundamental characteristics of fluid motion induced by the peristaltic motion as well as mixing and digestion of a simulated gastric chyme and a simulated digestive fluid.

Free Research Field

食品工学、生物化学工学