Mechanisms of glial development

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06719
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Keio University
• Principal Investigator: Shimazaki Takuya 慶應義塾大学, 医学部(信濃町), 准教授 (00324749)
• Research Collaborator: TSUYAMA Jun
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経幹細胞 / グリア / 分化 / マーカー

Outline of Final Research Achievements

We attempted to develop a system to visualize glial-restricted progenitors (GRPs) and/or transition state of neural stem cell (NSC) differentiation into glia. We identified Kcnj16 which is an inward-rectifier type potassium channel as a marker for GRPs or glial differentiation of NSCs via expression profiling to identify genes which respond to the temporal changes of gliogenic potency of NSCs during development and in situ hybridization analysis of expression pattern of candidate genes during central nervous system development. Finally, it has been suggested that a reporter system which can recapitulate the expression pattern of Kcnj16 can be applicable to visualize GRPs or glial differentiation of NSCs.

Free Research Field

神経発生学