Analysis of parallel computing of the corticospinal pathways in the primates

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06749
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Umeda Tatsuya 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 モデル動物開発研究部, 室長 (90376723)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 皮質脊髄路

Outline of Final Research Achievements

We labeled premotor neurons of rats using recombinant rabies virus in the pilot experiments. However, the labeling efficiency is quite low so that we could not try to label premotor neurons in macaque monkeys using the same labeling method. We tried to detect a connection between cortical neurons and spinal interneurons using GFP reconstitution across synaptic partners (GRASP) but did not any signals arose from GRASP. We examined the distribution of projection fibers of neurons in the primary motor cortex of a macaque monkey. We detected labeled fibers in the primary somatosensory cortex, which is considered to function in conveying efference copy signals to the somatosensory system.

Free Research Field

神経科学