Molecular mechanisms of mast cell tumorigenesis process

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06843
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Tokyo University of Science
• Principal Investigator: Abe Ryo 東京理科大学, 研究推進機構生命医科学研究所, 教授 (20159453)
• Co-Investigator(Kenkyū-buntansha): 小幡 裕希 東京理科大学, 研究推進機構生命医科学研究所, 講師 (20609408) ; 若松 英 東京理科大学, 研究推進機構生命医科学研究所, 助教 (40632617)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: マスト細胞腫 / Kitチロシンキナーゼ / PI3K-Akt / STAT5

Outline of Final Research Achievements

Previously, we established mast cell lines from mouse spleen and induced their autonomous proliferation by reducing cytokines that are required for normal mast cell growth. Furthermore, the mast cell line have characteristic features of mastocytoma cells. Thus, this experimental system help us to understand the mechanism of development of mast cell cancer.
In this study, we found that Kit autophosphorylation and activation of Erk and of Akt occur in the early stage of cancerization, whereas STAT5 activation is found only in the late phase. At present, analyses of molecular mechanism of the stage-specific activation of Kit,Erk, Akt, and STAT5 are under way.

Free Research Field

免疫学