2017 Fiscal Year Final Research Report
Elucidation of the structural basis of transporter proteins involved in metal tolerance
| Project/Area Number |
15K06972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
TANAKA Yoshiki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (10632333)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUKAZAKI Tomoya 奈良先端科学技術大学院大学, バイオサイエンス研究科, 准教授 (80436716)
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| Research Collaborator |
IWAKI Shigehiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | タンパク質構造 / 膜タンパク質 |
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| Outline of Final Research Achievements |
We conducted a crystal structure analysis on the multidrug efflux transporter MATE, which is a transporter related to plant metal tolerance, and reported its structure.
In the structure revealed, it became clear that some acidic amino acid side chains are concentrated in the inner pocket part. It was found that the aspect of the substrate binding region is different between the prokaryotic MATE which discharges hydrophobic substrates and the plant MATE which is related to emit cation such as aluminum.
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| Free Research Field |
X線結晶構造解析
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