2017 Fiscal Year Final Research Report
Molecular mechanism of new cellular functions mediated by polysialic acid
| Project/Area Number |
15K06995
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
SATO Chihiro 名古屋大学, 生物機能開発利用研究センター, 准教授 (10343211)
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| Research Collaborator |
Hane Masaya 名古屋大学, 生物機能開発利用研究センター, 研究員
Abe Chikara 名古屋大学, 大学院生命農学研究科, 学生
Mori Airi 名古屋大学, 大学院生命農学研究科, 学生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ポリシアル酸 / 精神疾患 / 神経細胞接着分子 / ポリシアル酸転移酵素 |
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| Outline of Final Research Achievements |
Polysiali acid (polySia/PSA) is present in brain and is involved in learning, memory and social interaction. So far, we have been demonstrated that polySia is involved in brain functions not only due to its large exclusion volume but also due to molecule binding properties. In this research, we demonstrated that polySia chains show characteristic features towards molecule-binding properties via biosynthetic enzymes, ST8SIA2 and ST8SIA4.
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| Free Research Field |
機能生物化学
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