Cellular function of moyamoya disease-associated protein mysterin

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Kyoto Sangyo University
• Principal Investigator: MORITO Daisuke 京都産業大学, タンパク質動態研究所, 主任研究員 (20514251)
• Research Collaborator: NAGATA Kazuhiro ; KOTANI Yuri ; SUGIHARA Munechika ; AINUKI Shiori
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ミステリン / モヤモヤ病 / 脂肪滴 / AAA+ / ユビキチン

Outline of Final Research Achievements

Moyamoya disease is a cerebrovascular disorder mostly observed in East Asian countries. It shows progressive stenosis and occlusion at internal carotid arteries, resulting in ischemia and cerebral infarction. Moreover, collateral vessels often rupture, resulting in patient death. We isolated mysterin gene, which was strongly associated with the onset of moyamoya disease; however, its function remained unknown. We recently succeeded in demonstrating that mysterin serves as a regulator of lipid metabolism with tissue culture cell system, for the first time.

Free Research Field

細胞生物学