2017 Fiscal Year Final Research Report
Visual neural activity regulates functional restoration of the photorecognition via neuropeptides during planarian brain regeneration
| Project/Area Number |
15K07148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Gakushuin University (2016-2017)
Kyoto University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 活動依存的 / 神経ペプチド / 脳再生 / 機能回復 / 環境応答行動 / 光応答行動 / プラナリア / 螺旋動物 |
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| Outline of Final Research Achievements |
A variety of external signals interpreted into defined neural functions play important role in the refinement of the neural function. Much remains to be understood how external signals contribute to the formation of the efficient neural system that supporting the transformation of the appropriate behavioral response against the complicated stimulus. Planarians display behaviors responsive to signals coming from outside such as light avoidance behavior, and the nervous system can be regenerated and its function completely restored even after decapitated, since the extraordinary regenerative capacity of planarians. We analyzed the molecular mechanisms of behavioral recovery during brain regeneration using RNAi and a behavioral assay in the planarian. Here we show that the novel neuropeptides contribute to the restitution of the proper phototactic behavior by modulating the photo-recognition during brain regeneration.
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| Free Research Field |
行動生理学、神経再生生物学、比較神経行動学
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