Mechanism of link between energy homeostasis and onset of differentiation in Streptomyces

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied microbiology
• Research Institution: Nihon University
• Principal Investigator: UEDA Kenji 日本大学, 生物資源科学部, 教授 (00277401)
• Co-Investigator(Kenkyū-buntansha): 高野 英晃 日本大学, 生物資源科学部, 准教授 (50385994) ; 西山 辰也 日本大学, 生物資源科学部, 助手 (10759541)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Streptomyces / energy metabolism / cell differentiation / secondary metabolism / homeostasis / transcription / regulation / antibiotics

Outline of Final Research Achievements

Antibiotic production and morphological differentiation in Streptomyces is stimulated by a high concentration of copper ion. Here, we revealed that the stimulation is based on the energy homeostatic mechanisms including the following systems: (1) negative regulation of ATP synthase operon by a transcriptional regulator Rex, and (2) positive regulation of succinate dehydrogenase operon by a specific LysR-type transcriptional regulator. Thus controlled intracellular energetic state may serve as a signal for the onset of development.

Free Research Field

応用微生物学