Experimental demonstration of the involvement of immune-mediated mechanism(s) for rapid manifestation of Kudoa food poisioning after consumption of raw fish

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Yamaguchi University
• Principal Investigator: Sato Hiroshi 山口大学, 共同獣医学部, 教授 (90211945)
• Co-Investigator(Kenkyū-buntansha): 柳田 哲矢 山口大学, 共同獣医学部, 准教授 (40431837)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Kudoa food poisoning / クドア食中毒 / marine fish / 海産魚 / Myxozoa / ミクソゾア / Myxosporea / 粘液胞子虫

Outline of Final Research Achievements

'Kudoa food poisoning' was newly recognized in 2011 as a human disease manifested by diarrhea and vomiting after consumption of fresh marine fish with Kudoa spores. Since pre-symptomatic time is 4 to 19 (average 5) hours after raw fish consumption, not only mechanical destruction of the epithelium of gastrointestinal mucosa, but also immune-mediated deterioration of mucosal lesion(s) might be suspected. To carry out laboratory demonstration using model systems, abundant numbers of Kudoa spores should be prepared. To find such sources of spores, commercially available marine fish were checked widely, and at last 12 known species and five new species were isolated from marine fish around Japan. It is finally concluded that bluespine unicornfish with Kudoa thalassomi, Carolines parrotfish, African coris, and Pasterl ringwrasse with Kudoa igami, all of which were fished in the sea around Miyako Island, Okinawa, could provide sufficient number of Kudoa spores for laboratory uses.

Free Research Field

寄生虫学