2017 Fiscal Year Final Research Report
Study on IgG involved in dietary allergies in dogs and cats
| Project/Area Number |
15K07757
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Keywords | 炭酸脱水酵素 / 食事性アレルギー / IgG抗体 / 腎疾患 |
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| Outline of Final Research Achievements |
We found a dog and cat that produced antibodies against carbonic anhydrase (CA) in serum. CA was antigenic in the pet food. Since CA is common antigenic among mammals, it is presumed that it is a dietary allergy. When the CA-3 IgG antibody was intramuscularly injected into rats, no decrease in muscle strength was observed, but the increase in muscle weight was suppressed.
CA-1, IgG antibody was intramuscularly injected into rats. On the 21th day after the administration, the whole blood was taken and a pathological specimen of the kidney was prepared. BUN, IP, Na, Cl, ALT, LDH, AMY, TG, T - CHO, HDL-C, clusterin, αGST and kIM-1 showed a significant increase in the blood test. In kidney pathological examination, degenerative necrosis was observed in the proximal tubule.
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| Free Research Field |
獣医生理学
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