2017 Fiscal Year Final Research Report
Regulation of three dimensional formation of renal tubule by Stat1
Project/Area Number |
15K07763
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrative animal science
|
Research Institution | Tokyo University of Agriculture and Technology |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 腎尿細管 / Stat1 / MDCK / カドヘリン16 |
Outline of Final Research Achievements |
Effect of wild-type or dominant negative form of Stat1 on tubule formation of canine renal epithelial cell-derived MDCK cells was examined. Wild-type Stat1 upregulated expression of kidney-specific cadherin 16 and induced formation of rigid and narrow tubule, while dominant negative Stat1-transfectant formed dilated and thin-walled tubule.
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Free Research Field |
獣医生化学
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