Roles of Superoxidedismutase in Central Glia for Protection from Oxidative Stress

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrative animal science
• Research Institution: Osaka Prefecture University
• Principal Investigator: Nakamura Yoichi 大阪府立大学, 生命環境科学研究科, 教授 (90180413)
• Co-Investigator(Kenkyū-buntansha): 森山 光章 大阪府立大学, 生命環境科学研究科, 准教授 (20275283) ; 高野 桂 大阪府立大学, 生命環境科学研究科, 准教授 (50453139)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞外スパーオキシドディスムターゼ / アストロサイト / 脳浮腫 / プリオン蛋白 / エキセンディン4

Outline of Final Research Achievements

Among three types of superoxidedismutase (SOD), extracellular type (EC-SOD) is abundant in astrocytes in CNS. We examined several stimulations on EC-SOD in astrocytes and found three interesting results. When the culture medium was diluted with water, as a brain edema model, EC-SOD activity increased significantly. The addition of exendin-4 (an agonist for GLP-1 receptor) increased the expression of EC-SOD in mRNA and protein. The stimulation with a fragment of prion protein (PrPc106-126) decreased EC-SOD activity to about 10%. These results suggest the importance of the studies focused on astrocytes for conquest of various central diseases due to oxidative stress.

Free Research Field

基礎獣医学