2017 Fiscal Year Final Research Report
Analysis of modification mechanism of reproductive regulation focusing on OGR1 family receptor
| Project/Area Number |
15K07772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | OGR1 / ゴナドトロフ / プロトン / 生殖調節 |
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| Outline of Final Research Achievements |
Reproductive regulation is controlled along the hypothalamic-pituitary-gonadal axis pathway. Here we show that OGR1 is expressed in rat pituitary gonadotropic cells and a mouse gonadotropic cell line. We also revealed that OGR1 is involved in activation of gene promoter accompanying pH decrease in the gonadotropic cell line. Furthermore, it was suggested that OGR1 may be involved in hormone secretion response due to pH decrease. These results suggest that OGR1 may be involved in reproductive regulation.
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| Free Research Field |
生理化学
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