Development of Iodine(III) Reagents with High Reactivity and Its Application to Metal-Free Cycloaddition-Type Reactions

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07852
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Saito Akio 東京農工大学, 工学(系)研究科(研究院), 准教授 (10339103)
• Research Collaborator: Zhdankin Viktor V. ミネソタ大学ダルース校, 化学科, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 超原子価ヨウ素 / 環化付加反応 / 触媒 / メタルフリー / 複素環化合物

Outline of Final Research Achievements

Iodine(III) compounds are less toxic and safe oxidants and are known to show reactivities similar to transition metals. However, compared with transition metal complexes, which are frequently used in the cycloaddition reaction for the synthesis of heterocycles, iodine(III) compounds show low reactivities and catalytic abilities. Therefore, new iodine(III) compounds with improved abilities of unsaturated bonds were developed, and then our self-developed metal-free cycloaddition reactions were improved and extended to catalytic methods as well as other cycloaddition reactions.

Free Research Field

有機合成化学