2017 Fiscal Year Final Research Report
Regulation of cell proliferation through tyrosine phosphorylation signaling in the nucleus
| Project/Area Number |
15K07922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山口 憲孝 千葉大学, 大学院薬学研究院, 准教授 (80399469)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 核内チロシンリン酸化 / Abl / Src / 転写因子 / 転写制御因子 / がん / シグナル伝達 / クロマチンリモデリング |
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| Outline of Final Research Achievements |
Abnormal tyrosine phosphorylation signaling causes major diseases, such as carcinogenesis, autoimmune diseases, diabetes, arteriosclerosis. In this study, we identified novel substrates of Src or Abl tyrosine kinase and determined their tyrosine phosphorylation sites. Consequently, we revealed that tyrosine phosphorylation of some nuclear transcription regulatory factors is involved in control of chromatin remodeling. It would be the first step to find a drug target having an excellent effect and less adverse effects, because tyrosine phosphorylation signaling in the nucleus has no divergent pathways and is located far downstream of the signal transduction pathways.
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| Free Research Field |
細胞生物学
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