Studies of roles of G proteins in integration of axon guidance signaling

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: Negishi Manabu 京都大学, 生命科学研究科, 教授 (60201696)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Ras / Rho / G protein / 神経 / 軸索 / 樹状突起 / スパイン / ガイダンス

Outline of Final Research Achievements

R-Ras subfamily small GTPases have essential roles in multiple phases of developments of neurons. We have examined the roles of TC21, a member of R-Ras subfamily, and we found that TC21 was specifically expressed in spines and promoted spine maturation through afadin, a downstream effector of TC21. We also examined the upstream of R-Ras for R-Ras-mediated axon outgrowth, and we found that RasGRF1 was a GEF for R-Ras and BDNF activated R-Ras through RasGRF1, promoting axon outgrowth.

Free Research Field

医歯薬学