2018 Fiscal Year Final Research Report
Characterization of combination effects of molecular targeted reagents based on the cell membrane bi-molecular cancer target
| Project/Area Number |
15K07941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
本家 孝一 高知大学, その他部局等, 副学長 (80190263)
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| Research Collaborator |
YAMAGUCHI arisa
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 肺がん / 分子会合体 / 分子標的薬 / 膜タンパク質 |
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| Outline of Final Research Achievements |
Here, we examined the cancer cell membrane-resident “cis-bimolecular complex as a possible cancer target. In vitro simulation of effective drug combinations used for multiple drug treatment strategy was performed using reagents targeted to cis-bimolecular complex. The combination treatment based on the information moderately suppressed cancer cell proliferation compared with single administration, suggesting that the information is profitable for the appropriate selection of the combination among molecular targeted reagents. Thus, cis-bimolecular complex has the possibility to make a contribution to several molecular targeted strategies in future.
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| Free Research Field |
医歯薬学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、現在様々な腫瘍治療に使用されている抗体医薬品を含む分子標的薬治療の治療前評価が可能になることが期待される。今後も、分子標的薬の使用は増え続けていくことが予想され、適切な薬剤選択は重要になると考えられる。
また、分子会合体情報を用いて分子標的薬剤併用効果について研究する試みは国内、国外においてもまだ実施された事例はなく、本研究により腫瘍薬物治療（抗がん剤治療）についての新規かつ重要な知見が得られると期待される。
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