The mechanism of anti-viral IgA production in respiratory tract

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07958
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Miyauchi Kosuke 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 副チームリーダー (50619856)
• Co-Investigator(Renkei-kenkyūsha): KUBO Masato 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (40277281)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: インフルエンザウイルス / IgA / 中和抗体 / サイトカイン

Outline of Final Research Achievements

Mucosal humoral immunity in respiratory tract is a major defense system against influenza virus infection. The mucosal IgA regulation in small intestine is well studied, however, less is known of mechanism of anti-virus IgA induction in respiratory tract. Here, we showed the secretion of IL-6 and IFN-g mediated by the viral replication in lung was critical for anti-virus IgA induction. Our experiments using Bcl6 deficient mice, which does not develop Tfh cells and germinal center B cells, revealed that Tfh cells and germinal centers were dispensable for the anti-virus IgA induction in lung. Our finding give the informative insight for development of novel mucosal anti-influenza vaccines.

Free Research Field

ウイルス学