Creation of therapeutic and preventive strategies for neurological diseases by low molecular weight functional molecules and compounds derived from foods

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07965
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Kyoto University
• Principal Investigator: Toshiaki Kume 京都大学, 薬学研究科, 准教授 (10303843)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経保護 / 脳疾患 / 抗酸化

Outline of Final Research Achievements

We have previously isolated DDC from green perilla leaves as an activator of the Nrf2-ARE pathway. Here, we showed the neuroprotective effect of DDC on PD models in vivo and in vitro. In a 6-OHDA-induced Parkinson's disease mouse model, intracerebral administration of DDC suppressed the dopaminergic neuronal loss and behavioral dysfunction. In primary mesencephalic cultures, DDC showed a protective effect against 6-OHDA-induced dopaminergic neuronal death. These results suggest that DDC prevents dopaminergic neurons from oxidative stress.

Free Research Field

薬理学