2017 Fiscal Year Final Research Report
A study on apelin as a new therapeutic target for glaucoma using apelin deficiency mouse
| Project/Area Number |
15K07983
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉岡 靖啓 摂南大学, 薬学部, 准教授 (40330360)
石丸 侑希 摂南大学, 薬学部, 助教 (80611607)
山室 晶子 摂南大学, 薬学部, 助手 (20340862)
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| Research Collaborator |
SUMINO Akihide 摂南大学, 薬学部, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アペリン / APJ / 緑内障 / 網膜神経節細胞 |
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| Outline of Final Research Achievements |
Glaucoma is a progressive eye disease that causes blindness through loss of retinal ganglion cells. Although progression of glaucoma is associated with elevation in intraocular pressure, in many patients, glaucomatous damage occurs with intraocular pressure in the normal range. Therefore, it is necessary to develop a new drug that inhibits retinal ganglion cell death in glaucoma. In the present study, we found that apelin, a bioactive peptide, protected against the loss of retinal ganglion cells in a mouse model of glaucoma. This suggests that apelin may be a new candidate for treating glaucoma.
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| Free Research Field |
薬物治療学
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