2017 Fiscal Year Final Research Report
Saponin production based on chemical variation of Glycyrrhiza plants
| Project/Area Number |
15K07999
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 甘草 / サポニン / カンゾウ属植物 / 成分変異 |
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| Outline of Final Research Achievements |
A glycyrrhizin(GL)-high-producing Glycyrrhiza uralensis strain (T628) was selected from various strains of Glycyrrhiza plants, and characterizations of the T628 strain and its offspring were performed to obtain better GL -high-producing strains. In addition, chemical characterization of Glycyrrhizin-Deficient-G. uralensis strains (83-555) were performed to isolate glucoglycyrrhizn (GGL), a unique analogue of GL. Offspring of 83-555 were characterized to obtain a vigorously-growing and GGL-producing strain (83-555-3-12) derived from a hybrid (83-555-3) of 83-555. Furthermore, Glycyrrhiza bucharica, an endemic Glycyrrhiza plant in Tajikistan, was shown to be closely related to GL -producing Glycyrrhiza species, G. uralensis, G. glabra and G. inflata, based on their chloroplast rbcL sequences, whereas G. bucharica do not produce GL. Four new triterpene glycosides, bucharosides A, B, C, D, were isolated and characterized from the underground parts of G. bucharica.
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| Free Research Field |
薬用植物学
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