Development of angiogenic therapy for ischemic heart disease using anaerobic vector

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08023
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Shinshu University
• Principal Investigator: WADA YUKO 信州大学, 学術研究院医学系(医学部附属病院), 講師 (30419410)
• Co-Investigator(Kenkyū-buntansha): 瀬戸 達一郎 信州大学, 学術研究院医学系, 准教授 (70362118)
• Research Collaborator: TANAKA Yuki 信州大学, 医学部, 技能補佐員
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 血管新生療法

Outline of Final Research Achievements

In this study we showed that B.Longum (BL), an anaerobic bacterium, accumulates specifically in the myocardial infarction site by intravenous administration, and are promptly removed from the non-ischemic site. This finding indicates that BL may be useful vector for ischemic heart disease.
We developed the new therapeutic angiogenesis drug for ischemic heart disease, FGF-BL incorporating bFGF gene into this vector, and performed a therapeutic experiment on guinea pig myocardial infarction model using FGF-BL. We confirmed that FGF-BL was specifically delivered to myocardial infarction site, but this agent did not show improvement effect for LV function.

Free Research Field

医歯薬学