2017 Fiscal Year Final Research Report
Study on the drug development for tumor immunotherapy based on immune-restoring activity of a plant ingredient betulin.
| Project/Area Number |
15K08041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Toyama Prefectural Institute. for Pharmaceutical Research. |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Nagai Yoshinori 富山大学, 大学院医学薬学研究部(医学), 准教授 (30431761)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 癌 / ベツリン |
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| Outline of Final Research Achievements |
Various factors dampen antitumor activity of immune cells in tumor microenvironment. Here we examined the antitumor mechanism of a derivate A of a plant product, betulin, which has recovering activity against immune cells suppressed by tumor. A derivative A remarkably inhibited the growth of EG7 cells subcutaneously implanted in mice. Moreover, increased expression of PD-L1 on EG7 cells is suggested to be responsible for augmentation of the antitumor activity of anti-PD-1 antibody.
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| Free Research Field |
薬理学
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