Dosage design and its evaluation for topically applicable DDS by focal unbound drug concentration monitoring

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Okayama University
• Principal Investigator: Kurosaki Yuji 岡山大学, 医歯薬学総合研究科, 教授 (90161786)
• Co-Investigator(Renkei-kenkyūsha): KIM Hye-Sook 岡山大学, 大学院医歯薬学総合研究科, 准教授 (70314664)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: 局所適用型DDS / 局所薬物動態モニタリング / マイクロダイアリシス / 吸着動態補正 / 固体分散体 / 含水ゲルシート

Outline of Final Research Achievements

The basic knowledge indispensable for designing the local application type DDS, which provides the localized pharmaceutical activities of drugs, was investigated by the ap-plication of microdialysis technique (MD). The localized diffusion process of topically applied model drug was monitored by MD and thus determined a focal availability concept for the local application type DDS was discussed. To improve the percutaneous absorption of drugs, solid-dispersions for low-water soluble drugs and L-HPC hydrogel sheet for dressing materials were investigated.

Free Research Field

薬物動態学