The Development of optimal dosage of anti-microbial agents based on PK/PD in patients with special pathological conditions

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08105
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Keio University
• Principal Investigator: MATSUMOTO Kazuaki 慶應義塾大学, 薬学部(芝共立), 教授 (60733160)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 抗菌薬 / PK/PD / 特殊病態 / 血液透析濾過 / 化膿性髄膜炎

Outline of Final Research Achievements

The development of optimal dosage of anti-microbial agents based on pharmacokinetics/pharmacodynamics (PK/PD) is an urgent issue. This study was acquired and analyzed PK data in patients with special pathological conditions (hemodiafiltration (HDF), meningitis, systemic inflammatory response syndrome (SIRS)). We revealed meropenem and cefazolin PK in patients with HDF, ceftazidime, cefepime, vancomycin and linezolid PK in patients of meningitis, and daptomycin PK in patients of SIRS, and then developed effective and safe dosing regimens for individual patients. The findings are immediately available for clinical setting and really helpful for proper use of anti-microbial agents.

Free Research Field

医療薬学