Multi-functions derived from the C-terminus of APC protein and their disorders

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Gifu University
• Principal Investigator: Senda Takao 岐阜大学, 大学院医学系研究科, 教授 (10187875)
• Co-Investigator(Kenkyū-buntansha): 東 華岳 産業医科大学, 医学部, 教授 (20273146)
• Research Collaborator: SHIMIZU Yoji 岐阜大学, 大学院医学系研究科, 大学院生 ; WANG Tuya 岐阜大学, 大学院医学系研究科, 大学院生 ; ISHIDA Hiroyasu 岐阜大学, 大学院医学系研究科, 大学院生 ; LI ChenGuang 岐阜大学, 大学院医学系研究科, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ＡＰＣ / ＡＰＣ1638Ｔ / 腸上皮 / 細胞増殖 / パネート細胞 / 内分泌細胞 / アポトーシス

Outline of Final Research Achievements

In the present study, various phenotypes of the APC (adenomatous polyposis coli) 1638T mouse were revealed. Cell number between the bottom of an intestinal crypt and the highest Ki-67 positive cell in the APC1638T mouse are more than that in wild-type one, suggesting the presence of ectopic proliferative cells. Though goblet cells and Paneth cells increased in number, endocrine cells decreased. Number of apoptotic cells per villus is more than that in wild-type one. These results suggest that C-terminus of APC protein is involved in maintenance of homeostasis in intestinal epithelium.

Free Research Field

発生学