Mechanisms for the manifestation of intracellular calcium dependent automaticity in the pulmonary-vein myocardium

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Toho University
• Principal Investigator: TANAKA Hikaru 東邦大学, 薬学部, 教授 (40236617)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺静脈心筋 / 活動電位 / 細胞内カルシウム / 心房細動

Outline of Final Research Achievements

Factors involved in the manifestation of the intracellular Ca2+-dependent automaticity were examined in pulmonary vein myocardium of guinea pigs, rats and mice. Acute and chronic stretch to the pulmonary vein enhanced the automatic activity through activation of stretch-activated ion channels. Alpha- and beta-adrenoceptor stimulation manifested the automaticity and pacemaker depolarization through enhancement of the Na+/Ca2+ exchanger, and the Ca2+ current and persistent Na+ current, respectively. Blockade of these ionic mechanisms was shown to be effective for the supression of pulmonary vein automaticity and probably atrial fibrillation.

Free Research Field

薬理学