2017 Fiscal Year Final Research Report
Intracellular M1-muscarinic acetylcholine receptors in central nervous system
| Project/Area Number |
15K08250
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
西尾 眞友 金沢医科大学, 医学部, 教授 (80156041)
益岡 尚由 金沢医科大学, 医学部, 准教授 (80509307)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | ムスカリン受容体 / アセチルコリン / コリン伝達機構 / トランスポーター / 記憶・学習 |
|---|
| Outline of Final Research Achievements |
M1-muscarinic acetylcholine receptors (M1-mAChRs) occur in not only cell surface but also intracelluar sites in CNS neurons and are associated with long term potentiation (LTP) in hippocampus, which has been known to be related to learning and memory. Intracellular M1-mAChRs are activated by ACh, which is transported to postsynaptic neurons though putative ACh transporter. Synaptic ACh concentations are regulated by ACh esterase, ACh transporter and presynaptic M2/M3 autoreceptors. The present study reveals a new aspect of cholinergic transmission in CNS.
|
| Free Research Field |
薬理学
|
