2017 Fiscal Year Final Research Report
Analysis of degradation mechanisms through WDR26 in Wnt signaling
| Project/Area Number |
15K08262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
GOTO Toshiyasu 東京医科歯科大学, 難治疾患研究所, 准教授 (00517518)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | WDR26 / Wnt / beta-catenin / ユビキチン化 / シグナル伝達 / アフリカツメガエル |
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| Outline of Final Research Achievements |
Wnt signaling pathway plays important roles in disease and embryonic development. Stability of cytoplasmic beta-catenin is a key feature of Wnt signaling pathway.
In this study, I first identified WDR26 as an Axin-binding protein by MS analysis. Then I analyzed the function of WDR26 in the degradation of beta-catenin of Wnt signaling pathway.
As results, I found that WDR 26 promoted beta-catenin ubiquitination through binding with Axin, other GID-related genes also ubiquitinated and reduced beta-catenin protein, novel lysine residues of were ubiquitinated during degradation of beta-catenin.
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| Free Research Field |
発生生物学
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