Functional analysis of epigenetic regulators in cancer development identified by retroviral insertional mutagenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08263
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: Suzuki Takeshi 金沢大学, がん進展制御研究所, 教授 (30262075)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: がん遺伝子 / エピジェネティクス / 非コードRNA / レトロウイルス / 挿入変異

Outline of Final Research Achievements

Retroviral insertional mutagenesis in mice is one of the powerful strategies for high-throughput identification of novel cancer genes. Using this system, we have frequently identified the genes encoding the enzymes engaged in histone methylation. We discovered that many of the enzymes are involved not only in the tumor initiation but also in the tumor progression such as cell invasion, epithelial mesenchymal transition and maintenance of stem cell properties. Furthermore, we found that long noncoding RNAs played a crucial role in the regulation of these epigenetic enzymes during malignant progression.

Free Research Field

分子生物学